Nominations for the Chemical Science Lectureship are closing on the 1st of March!
We are looking for researchers in the area of imaging, biosensing or diagnostics, that have published in Chemical Science in the past 5 years.
Find out more at https://rsc.li/chemsci-lectureship25
Nominations for our very first Chemical Science Lectureship will close soon, on the 1st of March. If you haven't nominated yet, now is the time!
This year we’re looking for researchers in the field of imaging, biosensing or diagnostics at any independent career stage who have published in the journal in the last five years.
Introduced for the 15th anniversary of the journal, the Chemical Science Lectureship will align with the topic of the Chemical Science Symposium for a given year.
Details about how to nominate are here:
https://rsc.li/chemsci-lectureship25
Nominate before 1st March 2025!
The winner will present their lectureship at the next Chemical Science symposium in November 2025 in a special Lectureship session, with associated travel costs included as part of the prize. They will also be invited to join the Chemical Science Advisory Board.
Researchers must be independent and have published in Chemical Science within the last 5 years. There are no requirements to have received a PhD within a set period for this Lectureship; candidates will be considered for contributions within the past five years.
Chemical Science is celebrating its 15th anniversary in 2025! We are publishing a special collection showcasing work from leading investigators from across all areas of chemistry who started their independent careers in the 15 years since
https://bsky.app/profile/chemsci.rsc.org was launched!
Read the 15th Anniversary: Chemical Science Leading Investigators collection here: https://rsc.li/sc-15li25
We hope that you enjoy reading this selection of articles, and that we can continue to provide an open and inclusive venue for researchers from across the chemical sciences for many years to come!
Check out some of the great articles already published in the collection:
“Periodic law-guided design of highly stable O3-type layered oxide cathodes for practical sodium-ion batteries” by Hai-Yan Hu, Yan-Fang Zhu, Yao Xiao, et al.
https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08351b
“Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines” by Hennie Valkenier et al.
https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08580a
“Engineering perfluoroarenes for enhanced molecular barrier effect and chirality transfer in solutions” by Aiyou Hao, Pengyao Xing, et al.
https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc07859d
First direct chemical synthesis of a gene over 1700 nucleotides long covered by Chemistry World!
Read the full paper in Chemical Science (which is free to read!) here:
https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc06958g
The Chemical Science Pick of the Week this week is “Discovery of fully synthetic FKBP12-mTOR molecular glues” by Felix Hausch and colleagues!
Read the manuscript for free, via Diamond Open Access, at https://doi.org/10.1039/D4SC06917J
Molecular glues are a drug modality with the potential to engage targets that are otherwise considered to be undruggable due to the lack of binding sites.
Through the help of an additional protein, the binding surface of the molecular glue-protein-complex can become sufficiently large to bind to flat and featureless protein surfaces with a high affinity.
Currently, molecular glues and molecular glue degrades are still largely discovered by serendipity and strategies for identifying them through rational and targeted means remain rare.
This work is reporting on the first fully synthetic KBP12-mTOR molecular glue, which can target flat surfaces. The authors show that screening at high target protein concentrations was crucial for the identification of a very weak hit, that would not have been as easily found via other approaches.
By utilizing the crystal structure, the authors were able to undertake rational design of the initial hit, leading to compounds which bind the FRB (FKBP-rapamycin 1 binding) domain of mTOR (mechanistic target of rapamycin 1) at nanomolar concentrations within cells, inhibiting functions of the complex.
Chemical Science is delighted to launch the first Lectureship associated with the journal as part of our 15th year anniversary in 2025!
This year, we are looking for researchers in the field of imaging, biosensing and diagnostics.
https://www.rsc.org/journals-books-databases/about-journals/chemical-science/chemsci-lectureship/
The Chemical Science Lectureship will celebrate leading, independent researchers at all career stages and who have made innovations in their field within the last five years.
The annual lectureship is focusing on a subject area that aligns with the next Chemical Science symposium, rotating each year to cover the diversity of topics published in the journal.
Researchers must be independent and have published in Chemical Science within the last 5 years. There are no requirements to have received a PhD within a set period for this Lectureship; candidates will be considered for contributions within the past five years.
The winner will present their lectureship at the next Chemical Science symposium in November 2025 in a special Lectureship session, with associated travel costs included as part of the prize. They will also be invited to join the Chemical Science Advisory Board.
Details about how to nominate are here:
https://www.rsc.org/journals-books-databases/about-journals/chemical-science/chemsci-lectureship/
Nominations are open until the 1st of March 2025 and we look forward to receiving your nominations!
I no longer work on
#ChemSci but please appreciate the phenomenal froggy cover artwork for this recent publication:
Surface proton hopping conduction mechanism dominant polymer electrolytes created by self-assembly of bicontinuous cubic liquid crystals
https://pubs.rsc.org/en/content/articlepdf/2024/sc/d4sc01211a
In the #ChemicalScience Pick of the Week. Anne McNeil et al. (University of Michigan, USA) provide an overview of poly(vinyl chloride) (PVC) functionalisation through a lens of chemical recycling, discussing various PVC reactivity trends and their applications with a critical assessment and future outlook of their recycling implications.
You can read the work here, in full and for free: https://pubs.rsc.org/doi/D3SC06758K
In our ChemSci Pick of the Week, Daniel Balzer and Ivan Kassal (University of Sydney, Australia) extend delocalised kinetic Monte Carlo (dKMC) to develop a three-dimensional model of charge generation that includes disorder, delocalisation, and polaron formation in every step from photoexcitation to charge separation.
You can read the work here, in full and for free: https://doi.org/10.1039/D3SC05409H
Help us choose the readers' favourite Chemical Science cover(s) from 2023:
https://smartsurvey.co.uk/s/ChemSciIFC23/
The top covers will be featured in our newsletter and the readers' favourite will win a prize! Could this cover be your favourite?
This week’s #ChemSciPicks comes from Patrick Holland at Yale University and looks at an unusual way to access a formally iron(IV) alkyl complexes to form an NNSi2 group. Check out the work here: https://doi.org/10.1039/D3SC05939A
All work published in Chemical Science is free to read via Diamond Open Access!
Jeremiah Gassensmith is an Associate Professor of Chemistry and Biochemistry at the University of Texas at Dallas. His research group uses well-defined nano- and micro-porous crystalline materials that nucleate and grow rapidly on protein, lipid and nucleic acid surfaces to create implantable or injectable composites for long-term protein delivery.
Read the work here, in full and for free via #ChemicalScience #DiamondOpenAccess: https://pubs.rsc.org/doi/D3SC06734C
In our ChemSci Pick of the Week, Jeremiah Gassensmith et al. (University of Texas at Dallas, USA) show that the biomimetic mineralisation of the inert model antigen ovalbumin (OVA) in zeolitic imidazolate framework-8 (ZIF-8) significantly improves the humoral immune response over three bolus doses of OVA (OVA 3×).
Read the work here, in full and for free: https://pubs.rsc.org/doi/D3SC06734C
#Chemistry #ChemSci #ChemicalScience #ChemSciPicks #Research #Publishing #OpenAccess
Help the #ChemicalScience editors choose the readers' favourite cover(s) from 2023: https://www.smartsurvey.co.uk/s/ChemSciOFC23/
The top covers will be featured in our newsletter and the readers' favourite will win a prize!
Choose your favourite outside front cover this month and stay tuned for more covers next month!
You love to see it 
If anyone would like to read more about this, I wrote a piece regaring the paper for Chemistry World (I wasn't involved in the review for Chemical Science!).
The paper is available here:
https://pubs.rsc.org/en/content/articlelanding/2023/sc/d2sc05709c
BarrierGNN is published in Chemical Science 
With it, we can predict reaction barriers of many HAT reactions in seconds. We use it in Collagen, but everybody can use it to predict HAT in various systems based on 3D structures.
Read our open-access paper here: https://doi.org/10.1039/d3sc03922f
Thanks to all Co-authors!
@graeter_mbm@twitter @grynova_CCC @P_Friederich@twitter @ktstiftung @chemistry
#CompChem #Chemistry #chemicalscience
#RSCPoster will be held on LinkedIn this year, on March 5th. If you'd like to start keeping up to date with news and research from Chemical Science on that platform check out
rsc.li/chemsci-linkedin
#RSCPoster is a great opportunity to share your chemistry research and connect with other chemists!
If you'd like more information on #RSCPoster please do head on over to the Royal Society of Chemistry event page here:
https://www.rsc.org/our-events/rsc-poster/
The #ChemSciPicks for this week is from Gabriel Loget, Neso Sojic and colleagues.
Infrared Photoinduced Electrochemiluminescence Microscopy of Single Cells
Read the paper, free via Diamond Open Access, here:
This week's Chemical Science Pick of the Week is "Small Molecular Adjuvant Repurposes Antibiotics towards Gram-negative Bacterial Infections and Multispecies Bacterial Biofilm", by Rajib Dey, Sudip Mukherjee, Riya Mukherjee and Jayanta Haldar from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bangalore, India.
Read it for free with #DiamondOpenAccess: https://doi.org/10.1039/D3SC05124B
In our #ChemSciPicks this Week, Henrik Sundén et al. (University of Gothenburg, Sweden) report a novel protocol for the long-standing challenge of regioselective ortho halogenation of N-aryl amides and ureas using an oxidative halodeboronation.
You can read the work here, for free: https://doi.org/10.1039/D3SC04628A
