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#dna

23 posts19 participants1 post today

And now something completely different. Yes sorry, I post various topics (see bio). My apologies to those who only follow me for my anti-fascism. ❤️

Clockwork: *Your Operating System |Eukaryotic Transcription*

youtube.com/watch?v=HZAmbbTcQ3

"🧬 How does your #DNA actually become who you are? Let's go on the incredible journey it takes to transcribe your DNA into #mRNA.

💻 Rendered using ‪Brady Johnston‬'s open-source Molecular Nodes Add-on for #Blender: extensions.blender.org/add-ons.

🏫 If you liked this overview, but you'd prefer something more comprehensive, I highly recommend the lectures on transcription produced by‪ theCrux‬: *Eukaryotic Transcription - Promoter Structure and Organization* youtube.com/watch?v=tZEWEQib_F "

🔴 **Inference of human pigmentation from ancient DNA by genotype likelihood**

_“We then applied that protocol to 348 ancient genomes from Eurasia, describing how skin, eye and hair color evolved over the past 45,000 years. The shift towards lighter pigmentations turned out to be all but linear in time and place, and slower than expected, with half of the individuals showing dark or intermediate skin colors well into the Copper and Iron ages.”_

Perretti, S. et al. (2025) 'Inference of human pigmentation from ancient DNA by genotype likelihood,' bioRxiv (Cold Spring Harbor Laboratory) [Preprint]. doi.org/10.1101/2025.01.29.635.

#Ancient #DNA #Genomes #Phenotype #Science #Eurasia #CopperAge #IronAge @science

bioRxiv · Inference of human pigmentation from ancient DNA by genotype likelihoodLight eyes, hair and skins probably evolved several times as Homo sapiens dispersed from Africa. In areas with lower UV radiation, light pigmentation alleles increased in frequency because of their adaptive advantage and of other contingent factors such as migration and drift. However, the tempo and mode of their spread is not known. Phenotypic inference from ancient DNA is complicated, both because these traits are polygenic, and because of low sequence depth. We evaluated the effects of the latter by randomly removing reads in two high-coverage ancient samples, the Paleolithic Ust’-Ishim from Russia and the Mesolithic SF12 from Sweden. We could thus compare three approaches to pigmentation inference, concluding that, for suboptimal levels of coverage (<8x), a probabilistic method estimating genotype likelihoods leads to the most robust predictions. We then applied that protocol to 348 ancient genomes from Eurasia, describing how skin, eye and hair color evolved over the past 45,000 years. The shift towards lighter pigmentations turned out to be all but linear in time and place, and slower than expected, with half of the individuals showing dark or intermediate skin colors well into the Copper and Iron ages. We also observed a peak of light eye pigmentation in Mesolithic times, and an accelerated change during the spread of Neolithic farmers over Western Eurasia, although localized processes of gene flow and admixture, or lack thereof, also played a significant role. ### Competing Interest Statement The authors have declared no competing interest.

#dna #MyHeritageDNA #myheritage Updated from My Heritage, so Scandinavian has went down to 1.8 Dane if you addup all the "Celtic" dna it comes up to 70% , anyhoo all a bit of nonsense imo, one side of my family came over from Ireland in the 1850s ,and worked as Slate and coal miners , according to my research,
so nae infamous or famous ancestors, just hard grafting working class people , and nowt wrong with that. 😁